2026-04-29T07:24:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/121812024-11-29T18:48:33Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Escala-Garcia, Maria author Abraham, Jean author Andrulis, Irene L author Anton-Culver, Hoda author Arndt, Volker author Ashworth, Alan author Auer, Paul L author Auvinen, Päivi author Beckmann, Matthias W author Beesley, Jonathan author Behrens, Sabine author Benitez, Javier author Bermisheva, Marina author Blomqvist, Carl author Blot, William author Bogdanova, Natalia V author Bojesen, Stig E author Bolla, Manjeet K author Børresen-Dale, Anne-Lise author Brauch, Hiltrud author Brenner, Hermann author Brucker, Sara Y author Burwinkel, Barbara author Caldas, Carlos author Canzian, Federico author Chang-Claude, Jenny author Chanock, Stephen J author Chin, Suet-Feung author Clarke, Christine L author Couch, Fergus J author Cox, Angela author Cross, Simon S author Czene, Kamila author Daly, Mary B author Dennis, Joe author Devilee, Peter author Dunn, Janet A author Dunning, Alison M author Dwek, Miriam author Earl, Helena M author Eccles, Diana M author Eliassen, A Heather author Ellberg, Carolina author Evans, D Gareth author Fasching, Peter A author Figueroa, Jonine author Flyger, Henrik author Gago-Dominguez, Manuela author Gapstur, Susan M author García-Closas, Montserrat author García-Sáenz, José A author Gaudet, Mia M author George, Angela author Giles, Graham G author Goldgar, David E author González-Neira, Anna author Grip, Mervi author Guénel, Pascal author Guo, Qi author Haiman, Christopher A author Håkansson, Niclas author Hamann, Ute author Harrington, Patricia A author Hiller, Louise author Hooning, Maartje J author Hopper, John L author Howell, Anthony author Huang, Chiun-Sheng author Huang, Guanmengqian author Hunter, David J author Jakubowska, Anna author John, Esther M author Kaaks, Rudolf author Kapoor, Pooja Middha author Keeman, Renske author Kitahara, Cari M author Kraft, Peter author Lambrechts, Diether author Le Marchand, Loic author Lejbkowicz, Flavio author Lindblom, Annika author Lubiński, Jan author Mannermaa, Arto author Manoochehri, Mehdi author Manoukian, Siranoush author Margolin, Sara author Martinez, Maria Elena author Maurer, Tabea author Mavroudis, Dimitrios author Meindl, Alfons author Milne, Roger L author Mulligan, Anna Marie author Neuhausen, Susan L author Nevanlinna, Heli author Newman, William G author Olshan, Andrew F author Olson, Janet E author Olsson, Håkan author Orr, Nick author Peterlongo, Paolo author Petridis, Christos author Prentice, Ross L author Presneau, Nadege author Punie, Kevin author Ramachandran, Dhanya author Rennert, Gad author Romero, Atocha author Sachchithananthan, Mythily author Saloustros, Emmanouil author Sawyer, Elinor J author Schmutzler, Rita K author Schwentner, Lukas author Scott, Christopher author Simard, Jacques author Sohn, Christof author Southey, Melissa C author Swerdlow, Anthony J author Tamimi, Rulla M author Tapper, William J author Teixeira, Manuel R author Terry, Mary Beth author Thorne, Heather author Tollenaar, Rob A E M author Tomlinson, Ian author Troester, Melissa A author Truong, Thérèse author Turnbull, Clare author Vachon, Celine M author van der Kolk, Lizet E author Wang, Qin author Winqvist, Robert author Wolk, Alicja author Yang, Xiaohong R author Ziogas, Argyrios author Pharoah, Paul D P author Hall, Per author Wessels, Lodewyk F A author Chenevix-Trench, Georgia author Bader, Gary D author Dörk, Thilo author Easton, Douglas F author Canisius, Sander author Schmidt, Marjanka K author Gonzalez Neira, Anna author Andrulis, Irene L. author Auer, Paul L. author Beckmann, Matthias W. author Bogdanova, Natalia V. author Bojesen, Stig E. author Bolla, Manjeet K. author Brucker, Sara Y. author Chanock, Stephen J. author Clarke, Christine L. author Couch, Fergus J. author Cross, Simon S. author Daly, Mary B. author Dunn, Janet A. author Dunning, Alison M. author Earl, Helena M. author Eccles, Diana M. author Eliassen, A. Heather author Evans, D. Gareth author Fasching, Peter A. author Gapstur, Susan M. author García-Sáenz, José A. author Gaudet, Mia M. author Giles, Graham G. author Goldgar, David E. author Haiman, Christopher A. author Harrington, Patricia A. author Hooning, Maartje J. author Hopper, John L. author Hunter, David J. author John, Esther M. author Kitahara, Cari M. author Koppert, Linetta B author Kristensen, Vessela N author Milne, Roger L. author Neuhausen, Susan L. author Newman, William G. author Olshan, Andrew F. author Olson, Janet E. author Prentice, Ross L. author Sawyer, Elinor J. author Schmutzler, Rita K. author Southey, Melissa C. author Swerdlow, Anthony J. author Tamimi, Rulla M. author Tapper, William J. author Tollenaar, Rob A. E. M. author Troester, Melissa A. author Vachon, Celine M. author van der Kolk, Lizet E. author Yang, Xiaohong R. author Pharoah, Paul D. P. author Wessels, Lodewyk F. A. author Bader, Gary D. author Easton, Douglas F. author Schmidt, Marjanka K. author 2020-11-01 Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis. Nat Commun.2020 ;11(1):312 http://hdl.handle.net/20.500.12105/12181 31949161 10.1038/s41467-019-14100-6 2041-1723 Nature communications A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.