2026-06-30T02:51:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/120652024-09-27T20:13:16Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Bernal-Martinez, Leticia
author
Gonçalves, S M
author
Andres, Belen de
author
Cunha, C
author
Gonzalez Jimenez, I
author
Lagrou, K
author
Mellado, Emilia
author
Gaspar, Maria Luisa
author
Maertens, J A
author
Carvalho, A
author
Alcazar-Fuoli, Laura
funder
Unión Europea. Comisión Europea. H2020
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación La Caixa
funder
Fundação para a Ciência e Tecnologia (Portugal)
2021-03-02T12:53:03Z
2021-03-02T12:53:03Z
2021-12
Virulence . 2021 Dec;12(1):570-583.
10.1080/21505594.2021.1879471
2150-5608
Virulence
33525982
http://hdl.handle.net/20.500.12105/12065
Pattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils and macrophages. A soluble form (sTREM1) of this protein that can be detected in human body fluids has been identified. Here we investigated the role of TREM1 during invasive pulmonary aspergillosis (IPA). IPA patients displayed significantly higher levels of sTREM1 in bronchoalveolar lavages when compared to control patients. Functional analysis in TREM1 showed that the levels of sTREM1 and TREM1 pathway-related cytokines were influenced by single nucleotide polymorphisms in TREM1. In addition, we confirmed a role of TREM1 on antifungal host defense against A. fumigatus in a murine model of IPA. TREM1 deficiency increased susceptibility to infection in the immunosuppressed murine host. Deletion of TREM1 showed delayed innate and adaptive immune responses and impaired pro-inflammatory cytokine responses. The absence of TREM1 in primary macrophages attenuated the TLR signaling by altering the expression of both receptor and effector proteins that are critical to the response against A. fumigatus. In this study, and for the first time, we demonstrate the key role for the TREM1 receptor pathway during IPA.
eng
Aspergillus fumigatus
TREM1
Diagnostic biomarkers and fungal immune response
TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis.
journal article
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TREM1RegulatesAntifungalImmune_2021.pdf
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TREM1RegulatesAntifungalImmune_2021.pdf.txt