2026-06-30T02:51:36Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/120652024-09-27T20:13:16Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Bernal-Martinez, Leticia author Gonçalves, S M author Andres, Belen de author Cunha, C author Gonzalez Jimenez, I author Lagrou, K author Mellado, Emilia author Gaspar, Maria Luisa author Maertens, J A author Carvalho, A author Alcazar-Fuoli, Laura author 2021-12 Pattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils and macrophages. A soluble form (sTREM1) of this protein that can be detected in human body fluids has been identified. Here we investigated the role of TREM1 during invasive pulmonary aspergillosis (IPA). IPA patients displayed significantly higher levels of sTREM1 in bronchoalveolar lavages when compared to control patients. Functional analysis in TREM1 showed that the levels of sTREM1 and TREM1 pathway-related cytokines were influenced by single nucleotide polymorphisms in TREM1. In addition, we confirmed a role of TREM1 on antifungal host defense against A. fumigatus in a murine model of IPA. TREM1 deficiency increased susceptibility to infection in the immunosuppressed murine host. Deletion of TREM1 showed delayed innate and adaptive immune responses and impaired pro-inflammatory cytokine responses. The absence of TREM1 in primary macrophages attenuated the TLR signaling by altering the expression of both receptor and effector proteins that are critical to the response against A. fumigatus. In this study, and for the first time, we demonstrate the key role for the TREM1 receptor pathway during IPA. Virulence . 2021 Dec;12(1):570-583. 10.1080/21505594.2021.1879471 2150-5608 Virulence 33525982 http://hdl.handle.net/20.500.12105/12065 Aspergillus fumigatus TREM1 Diagnostic biomarkers and fungal immune response TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis.