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oai:repisalud.isciii.es:20.500.12105/120252024-11-29T09:29:44Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16974

00925njm 22002777a 4500 dc Cañada-Garcia, Javier Enrique author Delgado, Elena author Gil, Horacio author Sanchez-Martinez, Monica author Benito, Sonia author Garcia-Bodas, Elena author Gómez-González, Carmen author Canut-Blasco, Andrés author Portu-Zapirain, Joseba author Sáez de Adana, Ester author De la Peña, Mireia author Ibarra, Sofía author Cilla, Gustavo author Iribarren, José Antonio author Martínez-Sapiña, Ana author Thomson, Michael M author 2021-01-12 The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains. Viruses. 2021 Jan 12;13(1):93. 10.3390/v13010093 1999-4915 Viruses 33445523 http://hdl.handle.net/20.500.12105/12025 HIV-1 HIV-1 genetic diversity HIV-1 molecular epidemiology HIV-1 phylogeny Circulating recombinant form. Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain.