2026-05-22T00:32:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/118552025-06-12T13:29:20Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Martinez, Isidoro
author
Ryan, Pablo
author
Valencia, Jorge
author
Resino, Salvador
funder
Instituto de Salud Carlos III
funder
Gilead Sciences (Spain)
2021-02-12T07:44:39Z
2021-02-12T07:44:39Z
2021-02-05
J Clin Med . 2021 Feb 5;10(4):611.
10.3390/jcm10040611
2077-0383
Journal of clinical medicine
33562818
http://hdl.handle.net/20.500.12105/11855
Hepatitis C virus (HCV) infection remains a substantial health problem as a leading cause of chronic liver disease worldwide [1]. Chronic hepatitis C (CHC) develops in 75–100% of patients who remain plasma HCV-RNA positive after acute hepatitis C. The World Health Organization (WHO) has estimated that there are about 71 million individuals with CHC worldwide, many of whom are unaware of their infections [1]. CHC causes persistent liver inflammation, leading to cirrhosis development in approximately 10–20% of patients after 20–30 years of HCV infection. Cirrhotic patients have a 1–5% annual risk of developing hepatocellular carcinoma and a 3–6% risk of hepatic decompensation. Following an episode of decompensation, the risk of death in the following year is between 15 and 20% [2].
eng
The Challenging Road to Hepatitis C Virus Eradication
research article
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URL
https://repisalud.isciii.es/bitstreams/145a3558-2c12-448a-983c-547cb2d38888/download
File
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TheChallengingRoadTo_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/ea3748ac-faf2-46c4-9e18-279e491a8c50/download
File
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text/plain
TheChallengingRoadTo_2021.pdf.txt