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00925njm 22002777a 4500 dc Lope Carvajal, Virginia author Guerrero-Zotano, Ángel author Casas, Ana María author Baena-Cañada, José Manuel author Bermejo, Begoña author Perez-Gomez, Beatriz author Criado-Navarro, Inmaculada author Antolín, Silvia author Sánchez-Rovira, Pedro author Ramos-Vázquez, Manuel author Antón, Antonio author Castelló Pastor, Adela author García-Sáenz, José Ángel author Muñoz, Montserrat author de Juan, Ana author Andrés, Raquel author Llombart-Cussac, Antonio author Hernando, Blanca author Franquesa, Rosa María author Caballero, Rosalia author Priego-Capote, Feliciano author Martín, Miguel author Pollan-Santamaria, Marina author 2020-10-14 This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. Nutrients . 2020 Oct 14;12(10):3132. 10.3390/nu12103132 2072-6643 Nutrients 33066483 http://hdl.handle.net/20.500.12105/11813 EpiGEICAM Breast cancer subtypes Breast neoplasm Desaturation indices Fats Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.