2026-08-31T05:44:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/117912025-03-10T13:11:55Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_19604col_20.500.12105_19614col_20.500.12105_19605
Repisalud
author
Laclaustra, Martin
author
Van Den Berg, Elizabeth Louise Maayken
author
Hurtado-Roca, Yamilee
author
Castellote, Juan Manuel
funder
Instituto de Salud Carlos III
funder
Gobierno de Perú
2021-02-03T12:50:11Z
2021-02-03T12:50:11Z
2015
PLoS One. 2015 Feb 23;10(2):e0115522.
10.1371/journal.pone.0115522
1932-6203
PloS one
25706982
http://hdl.handle.net/20.500.12105/11791
Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study). A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex. Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p<0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample. A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.
eng
Serum lipid profile in subjects with traumatic spinal cord injury
research article
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URL
https://repisalud.isciii.es/bitstreams/206e914b-fd88-49e2-8e19-56063a907ff0/download
File
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application/pdf
SerumLipidProfileIn_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/0d8201ae-694f-44d0-98b9-0553bb8df65a/download
File
MD5
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text/plain
SerumLipidProfileIn_2015.pdf.txt