2026-07-25T15:28:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/117862025-05-29T11:06:09Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
de Lucas, Maria Pilar
author
Jimenez, Marta
author
Sanchez-Pavon, Paloma
author
Saez, Alberto G
author
Lozano, Encarnacion
funder
Instituto de Salud Carlos III
2021-02-03T10:46:54Z
2021-02-03T10:46:54Z
2021-01-11
Int J Mol Sci . 2021 Jan 11;22(2):638.
10.3390/ijms22020638
1422-0067
International journal of molecular sciences
33440633
http://hdl.handle.net/20.500.12105/11786
Transforming growth factor β (TGF-β) signalling pathways are highly conserved across metazoa and play essential roles not only during development but also in adult tissue maintenance. Alterations of these pathways usually result in a plethora of pathologies. In the nematode Caenorhabditis elegans, the TGF-β Sma/Mab (small/male abnormal) pathway regulates various worm phenotypes such as body size, immune response, ageing, matricide and reproductive span. SMA-10 has been described as a positive modulator of worm body size through the TGF-β Sma/Mab pathway. To better understand if SMA-10 is a core component of the pathway, we use gene epistatic analysis to assess the contribution of SMA-10 to various phenotypes regulated by TGF-β Sma/Mab. We confirm that SMA-10 controls body size and find that it also affects the matricide and reproductive span of the nematodes. However, neither male tail formation (previously reported) nor ageing appeared altered. Lastly, although null sma-10 worms are more susceptible to Pseudomonas aeruginosa infections than wild-types, this response does not depend on TGF-β Sma/Mab but on the insulin receptor DAF-2. We also show that the expression of sma-10 in either hypodermis or intestine fully rescues the wild-type immune response. Our results contribute to understanding the role of SMA-10 as a context-dependent component of TGF-β Sma/Mab, and reveal a function of SMA-10 in immunity in association to the Insulin/insulin-like growth factor signalling (IIS) pathway.
eng
IIS pathway
TGF-β Sma/Mab
TGF-β signalling
daf-2
Innate immunity
sma-10
SMA-10 Is a Non-Canonical Member of the TGF-β Sma/Mab Pathway and Immunity Regulator via the DAF-2 Insulin Receptor in Caenorhabditis elegans
research article
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URL
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SMA10IsANon_2021.pdf
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https://repisalud.isciii.es/bitstreams/54ccf34b-34de-43f2-9681-fb89d7e4e683/download
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SMA10IsANon_2021.pdf.txt