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00925njm 22002777a 4500 dc Alonso-Molero, Jéssica author Dierssen-Sotos, Trinidad author Gómez-Acebo, Inés author Fernandez de Larrea-Baz, Nerea author Guevara, Marcela author Amiano, Pilar author Castaño-Vinyals, Gemma author Fernández-Villa, Tania author Moreno, Victor author Bayo, Juan author Molina-Barceló, Ana author Fernández-Ortíz, María author Suarez-Calleja, Claudia author Marcos-Gragera, Rafael author Castells, Xavier author Gil-Majuelo, Leire author Ardanaz, Eva author Perez-Gomez, Beatriz author Kogevinas, Manolis author Pollan-Santamaria, Marina author Llorca, Javier author 2020 Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017-2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run. Int J Environ Res Public Health . 2020 Nov 13;17(22):8411. 10.3390/ijerph17228411 1660-4601 International journal of environmental research and public health 33202919 http://hdl.handle.net/20.500.12105/11751 FBSI SF-12 Breast cancer Educational level Quality of life Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study