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oai:repisalud.isciii.es:20.500.12105/116802024-11-28T16:29:25Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938

00925njm 22002777a 4500 dc Sandonís, Virginia author Garcia-Rios, Estefani author McConnell, Michael J author Perez-Romero, Pilar author 2020-11 Cytomegalovirus (CMV) infection elicits a potent immune response that includes the stimulation of antibodies with neutralizing activity. Recent studies have focused on elucidating the role of neutralizing antibodies in protecting against CMV infection and disease and characterizing viral antigens against which neutralizing antibodies are directed. Here, we provide a synthesis of recent data regarding the role of neutralizing antibodies in protection against CMV infection/disease. We consider the role of humoral immunity in the context of the global CMV-specific immune response, and the implications that recent findings have for vaccine and antibody-based therapy design. Trends Microbiol. 2020 Nov;28(11):900-912. 10.1016/j.tim.2020.04.003 1878-4380 Trends in microbiology 32448762 http://hdl.handle.net/20.500.12105/11680 CMV-specific immune response Antibody-based therapeutics Cytomegalovirus Neutralizing antibodies Vaccine design Role of Neutralizing Antibodies in CMV Infection: Implications for New Therapeutic Approaches