2026-08-05T09:50:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/116762025-05-05T13:30:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez-Jimenez, Irene
author
Lucio, Jose
author
Menéndez-Fraga, Maria Dolores
author
Mellado, Emilia
author
Pelaez, Teresa
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
RETICS-Investigación en Patología Infecciosa (REIPI-ISCIII) (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2021-01-26T09:26:38Z
2021-01-26T09:26:38Z
2021-01-02
J Fungi (Basel) . 2021 Jan 2;7(1):22
10.3390/jof7010022
2309-608X
Journal of fungi (Basel, Switzerland)
33401764
http://hdl.handle.net/20.500.12105/11676
Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A. fumigatus hospital colonization in a patient is reported here. Investigations of the hospital environment led to the recovery of A. fumigatus strains harboring the TR34/L98H and the G448S Cyp51A azole resistance mechanisms. Isolate genotyping showed that one strain from the environment was isogenic with the patient strains. These are the first environmental A. fumigatus azole resistant strains collected in a hospital in Spain; it supports the idea of the hospital environment as a source of dissemination and colonization/infection by azole resistant A. fumigatus in patients. The isolation of an azole-resistant strain from an azole-naïve patient is an interesting finding, suggesting that an effective analysis of clinical and environmental sources must be done to detect azole resistance in A. fumigatus. The emergence and spread of these resistance mechanisms in A. fumigatus is of major concern because it confers high resistance to voriconazole and is associated with treatment failure in patients with invasive aspergillosis.
eng
Aspergillus fumigatus
Azole resistance mechanisms
cyp51A
Hospital environment
Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations
research article
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URL
https://repisalud.isciii.es/bitstreams/573c4eb7-bb40-4a82-8a19-f8e09c90c297/download
File
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application/pdf
HospitalEnvironmentAsA_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/2f9ab0fc-7f3e-4537-8bb3-bb806edca2fb/download
File
MD5
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text/plain
HospitalEnvironmentAsA_2021.pdf.txt