2026-05-22T11:08:25Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/116722025-05-08T11:17:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Alfayate Miguélez, Santiago author Yague Guirao, Genoveva author Menasalvas Ruíz, Ana I author Sánchez-Solís, Manuel author Gonzalez-Camacho, Fernando author Ortíz Romero, M Mar author Espejo García, Pilar author Guerrero Gómez, Carmen author Iofrío de Arce, Antonio author Moreno Parrado, Laura author Sánchez Andrada, Rosa M author Cascales Alcolea, Eva author Lorente García, Sebastián author Paredes Reyes, Pedro author Casquet Barceló, Ángela author López Yepes, M Luisa author Vigueras Abellán, Juan José author Sanz Mateo, Gonzalo author Domenech Lucas, Mirian author Murcian Pneumococcal Study Group author 2020-12-28 Background: An epidemiological study of Streptococcus pneumoniae nasopharyngeal carriage in healthy children was carried out five years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Objectives: Study the impact of pediatric vaccination with PCV13, and other associated epidemiological factors on the status of nasopharyngeal carriage, the circulating pneumococcal serotypes, and the antibiotic susceptibility to more frequently used antibiotics. Methods: A multi-center study was carried out in Primary Health Care, which included 1821 healthy children aged 1 to 4 years old. All isolates were sent to the Spanish Pneumococcal Reference Laboratory for serotyping and antimicrobial susceptibility testing. Results: At least one dose of PCV13 had been received by 71.9% of children and carriage pneumococcal prevalence was 19.7%. The proportion of PCV13 serotypes was low (14.4%), with an observed predominance of non-vaccine serotypes, 23B, 11A, 10A, 35B/F, and 23A were the five most frequent. A high rate of resistance to penicillin, erythromycin, and trimethoprim sulfamethoxazole was found. Conclusions: A low proportion of PCV13 serotypes were detected, confirming the impact of pediatric vaccination for reducing the serotypes vaccine carriage. High resistance rates to clinically important antibiotics were observed. Vaccines (Basel). 2020 Dec 28;9(1):E14. 10.3390/vaccines9010014 2076-393X Vaccines 33379235 http://hdl.handle.net/20.500.12105/11672 Streptococcus pneumoniae nasopharyngeal carriage Antimicrobial susceptibility Conjugate vaccines Impact of Pneumococcal Vaccination in the Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children of the Murcia Region in Spain