2026-06-14T03:40:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/116712025-06-13T08:20:27Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Moreno-García, Alexandra
author
Kun, Alejandra
author
Calero, Miguel
author
Calero, Olga
funder
Ministerio de Economía y Competitividad (España)
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
2021-01-25T19:38:45Z
2021-01-25T19:38:45Z
2021-01-16
Antioxidants (Basel) . 2021 Jan 16;10(1):E124.
10.3390/antiox10010124
2076-3921
Antioxidants (Basel, Switzerland)
33467040
http://hdl.handle.net/20.500.12105/11671
Aging is associated with an increasing dysfunction of key brain homeostasis mechanisms and represents the main risk factor across most neurodegenerative disorders. However, the degree of dysregulation and the affectation of specific pathways set apart normal aging from neurodegenerative disorders. In particular, the neuronal metabolism of catecholaminergic neurotransmitters appears to be a specifically sensitive pathway that is affected in different neurodegenerations. In humans, catecholaminergic neurons are characterized by an age-related accumulation of neuromelanin (NM), rendering the soma of the neurons black. This intracellular NM appears to serve as a very efficient quencher for toxic molecules. However, when a neuron degenerates, NM is released together with its load (many undegraded cellular components, transition metals, lipids, xenobiotics) contributing to initiate and worsen an eventual immune response, exacerbating the oxidative stress, ultimately leading to the neurodegenerative process. This review focuses on the analysis of the role of NM in normal aging and neurodegeneration related to its capabilities as an antioxidant and scavenging of harmful molecules, versus its involvement in oxidative stress and aberrant immune response, depending on NM saturation state and its extracellular release.
eng
Immune response
Neurodegeneration
Neuromelanin (NM)
Oxidative stress
Reactive oxygen species (ROS)
The Neuromelanin Paradox and Its Dual Role in Oxidative Stress and Neurodegeneration.
research article
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URL
https://repisalud.isciii.es/bitstreams/21dfe54b-bde9-4487-93b1-5d12e82c725f/download
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TheNeuromelaninParadoxAnd_2021.pdf
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https://repisalud.isciii.es/bitstreams/2fb52670-6e75-4af1-a32a-4404c6607148/download
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TheNeuromelaninParadoxAnd_2021.pdf.txt