2026-04-19T12:48:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/116702025-06-13T08:30:31Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Segura-Collar, Berta
author
Mata-Martínez, Pablo
author
Hernández-Laín, Aurelio
author
Sánchez-Gómez, Pilar
author
Gargini, Ricardo
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2021-01-25T18:59:39Z
2021-01-25T18:59:39Z
2021-01-15
Neuroscientist. 2022 Jun;28(3):222-237.
http://hdl.handle.net/20.500.12105/11670
33446074
10.1177/1073858420985838
1089-4098
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
The brain is endowed with a unique cellular composition and organization, embedded within a vascular network and isolated from the circulating blood by a specialized frontier, the so-called blood-brain barrier (BBB), which is necessary for its proper function. Recent reports have shown that increments in the permeability of the blood vessels facilitates the entry of toxic components and immune cells to the brain parenchyma and alters the phenotype of the supporting astrocytes. All of these might contribute to the progression of different pathologies such as brain cancers or neurodegenerative diseases. Although it is well known that BBB breakdown occurs due to pericyte malfunctioning or to the lack of stability of the blood vessels, its participation in the diverse neural diseases needs further elucidation. This review summarizes what it is known about BBB structure and function and how its instability might trigger or promote neuronal degeneration and glioma progression, with a special focus on the role of pericytes as key modulators of the vasculature. Moreover, we will discuss some recent reports that highlights the participation of the BBB alterations in glioma growth. This pan-disease analysis might shed some light into these otherwise untreatable diseases and help to design better therapeutic approaches.
eng
Blood-brain barrier (BBB)
Neurovascular unit (NVU)
Pericytes
Neurodegeneration
Glioma
Alzheimer’s disease
Blood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases
research article
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URL
https://repisalud.isciii.es/bitstreams/f2ccce4a-767c-46a5-9f5f-44ab6cb41d5f/download
File
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application/pdf
BloodBrainBarrierDisruption_2021.pdf
URL
https://repisalud.isciii.es/bitstreams/626c71e8-2e05-4d49-a140-8314db41560e/download
File
MD5
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text/plain
BloodBrainBarrierDisruption_2021.pdf.txt