2026-06-30T21:29:28Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/116482025-05-05T13:30:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Medina, Narda author Soto-Debran, Juan Carlos author Seidel, Danila author Akyar, Isin author Badali, Hamid author Barac, Aleksandra author Bretagne, Stéphane author Cag, Yasemin author Cassagne, Carole author Castro, Carmen author Chakrabarti, Arunaloke author Dannaoui, Eric author Cardozo, Celia author García-Rodríguez, Julio author Guitard, Juliette author Hamal, Petr author Hoenigl, Martin author Jagielski, Tomasz author Khodavaisy, Sadegh author Lo Cascio, Giuliana author Martínez-Rubio, María Carmen author Meletiadis, Joseph author Muñoz, Patricia author Ochman, Elżbieta author Pelaez, Teresa author Perez-Ayala Balzola, Ana author Prattes, Juergen author Roilides, Emmanuel author Ruíz-Pérez de Pipaón, Maite author Stauf, Raphael author Steinmann, Jörg author Suárez-Barrenechea, Ana Isabel author Tejero, Rocío author Trovato, Laura author Viñuela, Lourdes author Wongsuk, Thanwa author Żak, Iwona author Zarrinfar, Hossein author Lass-Flörl, Cornelia author Alastruey-Izquierdo, Ana author 2021 Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. J Fungi (Basel). 2021;7(1):e13. 10.3390/jof7010013 2309-608X Journal of fungi (Basel, Switzerland) 33383783 http://hdl.handle.net/20.500.12105/11648 Candida Chrome agar Invasive candidiasis Mix infections Polymicrobial infections Yeast MixInYeast: A Multicenter Study on Mixed Yeast Infections