2026-07-22T05:26:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/116382024-09-27T20:46:48Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Ordikhani, Farideh
author
Pothula, Venu
author
Sanchez-Tarjuelo, Rodrigo
author
Jordan, Stefan
author
Ochando, Jordi
funder
National Institutes of Health (Estados Unidos)
2021-01-19T09:46:31Z
2021-01-19T09:46:31Z
2020
Front Immunol . 2020 Nov 30;11:582939.
10.3389/fimmu.2020.582939
1664-3224
Frontiers in immunology
33329555
http://hdl.handle.net/20.500.12105/11638
Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in graft rejection, as these mononuclear phagocytic cells recognize alloantigens and trigger an inflammatory cascade that activate the adaptive immune response. Moreover, recent studies suggest that monocytes acquire a feature of memory recall response that is associated with a potent immune response. This form of memory is called "trained immunity," and it is retained by mechanisms of epigenetic and metabolic changes in innate immune cells after exposure to particular ligands, which have a direct impact in allograft rejection. In this review article, we highlight the role of monocytes and macrophages in organ transplantation and summarize therapeutic approaches to promote tolerance through manipulation of monocytes and macrophages. These strategies may open new therapeutic opportunities to increase long-term transplant survival rates in the clinic.
eng
Immune tolerance
Macrophages
Nanotherapy
Organ transplantation
Trained immunity
Macrophages in Organ Transplantation.
journal article
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MacrophagesInOrganTransplantation_2020.pdf
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MacrophagesInOrganTransplantation_2020.pdf.txt