2026-07-21T21:47:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/115962024-11-29T11:18:18Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16982col_20.500.12105_19617

00925njm 22002777a 4500 dc Oeo-Santos, Carmen author Navas, Ana author Benedé, Sara author Ruíz-León, Berta author Díaz-Perales, Araceli author Vogel, Lothar author Moreno-Aguilar, Carmen author Jurado, Aurora author Villalba, Mayte author Barderas Manchado, Rodrigo author 2020 Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7-sensitized patients exhibit a co-sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross-reactivity, which explains this observed co-sensitization. Therefore, the purpose of this study was to explore the relationship between Ole e 7 and Pru p 3. A total of 48 patients sensitized to Ole e 7 and/or Pru p 3 were included in the study. Specific IgE serum levels were measured by ImmunoCAP 250 and ELISA. Inhibition assays were performed to determine the existence of cross-reactivity between both nsLTPs. Allergic response was analyzed ex vivo (basophil activation test) and in vitro (RBL-2H3 mast cell model). Common IgG and IgE epitopes were identified between both allergens. IgE-binding inhibition was detected in Ole e 7-monosensitized patients using rPru p 3 as inhibitor, reaching inhibition values of 25 and 100%. Ex vivo and in vitro assays revealed a response against rPru p 3 in four (31%) Ole e 7-monosensitized patients. Our results suggest that Ole e 7 could play a new role as primary sensitizer in regions with high olive pollen exposure, leading to the peach nsLTP sensitization. This co-sensitization process would occur because of the cross-reactivity between Ole e 7 and Pru p 3 observed in some allergic patients. Allergy. 2020 Apr;75(4):798-807. 10.1111/all.14086 1398-9995 Allergy 31605380 http://hdl.handle.net/20.500.12105/11596 Cross-reactivity Non-specific Lipid Transfer Protein Olive pollinosis Peach allergy Primary sensitization New insights into the sensitization to nonspecific lipid transfer proteins from pollen and food: New role of allergen Ole e 7