2026-06-14T03:40:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/115802024-09-27T18:38:17Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609
Repisalud
author
Mazagatos, Clara
author
Godoy, Pere
author
Muñoz Almagro, Carmen
author
Larrauri, Amparo
author
Pozo Sanchez, Francisco
author
IVE in Pregnant Women Working Group
author
Delgado-Sanz, Concepcion
author
Oliva Dominguez, Jesus Angel
author
Gherasim, Alin Manuel
author
Gallego Berciano, Pilar
2021-01-08T08:11:29Z
2021-01-08T08:11:29Z
2020-12-14
Vaccine. 2020 Dec 14;38(52):8405-8410.
10.1016/j.vaccine.2020.07.014
1873-2518
Vaccine
32741669
http://hdl.handle.net/20.500.12105/11580
Introduction: Influenza vaccination is recommended to pregnant women in Spain to reduce the risk of influenza-related complications. Influenza related hospitalizations pose a significant disease burden in children every year. Although children below 6 months are too young to be vaccinated, they can receive protection against influenza through vaccination of their mothers during pregnancy. We estimated the effectiveness of maternal influenza vaccination to prevent influenza hospitalizations in infants under 6 months of age. Methods: This is a retrospective pilot study, using data from the Severe Hospitalized Confirmed Influenza Cases (SHCIC) surveillance system in seasons 2017/18 and 2018/19 in Spain. Maternal vaccination status during pregnancy was collected for cases in children 6 months and younger hospitalized with confirmed influenza infection. Influenza vaccine effectiveness was estimated using the screening method, by comparing the proportion of children with vaccinated mothers during pregnancy (proportion of cases vaccinated, PCV), with the vaccination coverage among pregnant women in Spain (proportion of population vaccinated, PPV). Results: For all the study period, the PCV was 17% and the PPV was 35%. Influenza vaccination in mothers during pregnancy prevented influenza confirmed hospitalizations in infants aged 6 months and younger with a 61% (95%CI: 27-79%) effectiveness. Conclusions: In line with evidence from other countries, influenza vaccination during pregnancy protects infants up to 6 months of age from influenza hospitalizations in Spain. These results support current recommendations of influenza vaccination in pregnant women, and more studies are needed in Spain to confirm the double protection of maternal vaccination in mothers and infants.
eng
Influenza
Vaccine
Pregnancy
Screening
Effectiveness of influenza vaccination during pregnancy to prevent severe infection in children under 6 months of age, Spain, 2017-2019
research article
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EffectivenessOfInfluenzaVaccination_2020.pdf
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EffectivenessOfInfluenzaVaccination_2020.pdf.txt