2026-08-29T07:31:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/115672024-09-27T09:17:50Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rubio-Ponce, Andrea
author
Hidalgo, Andres
author
Ballesteros, Ivan
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Fondation Leducq
funder
Fundación ProCNIC
2020-12-29T09:42:09Z
2020-12-29T09:42:09Z
2020-10-07
Curr Opin Immunol. 2020; 68:41-47
10.1016/j.coi.2020.08.003
0952-7915
Current opinion in immunology
33038850
http://hdl.handle.net/20.500.12105/11567
Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.
eng
How to bridle a neutrophil.
journal article
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URL
https://repisalud.isciii.es/bitstreams/0116f665-5c39-4f74-8d9d-e9759e9c9e1e/download
File
MD5
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application/pdf
HowBridleNeutrophil_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/041a7640-cfae-4e33-a103-cef8f069e4ea/download
File
MD5
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text/plain
HowBridleNeutrophil_2020.pdf.txt