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oai:repisalud.isciii.es:20.500.12105/115672024-09-27T09:17:50Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Rubio-Ponce, Andrea author Hidalgo, Andres author Ballesteros, Ivan author 2020-10-07 Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit. Curr Opin Immunol. 2020; 68:41-47 10.1016/j.coi.2020.08.003 0952-7915 Current opinion in immunology 33038850 http://hdl.handle.net/20.500.12105/11567 How to bridle a neutrophil.