2026-08-10T01:24:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/115662024-09-27T08:20:00Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Ballesteros, Ivan
author
Rubio-Ponce, Andrea
author
Genua, Marco
author
Lusito, Eleonora
author
Kwok, Immanuel
author
Fernández-Calvo, Gabriel
author
Khoyratty, Tariq E
author
van Grinsven, Erinke
author
Gonzalez-Hernandez, Sara
author
Nicolás-Ávila, José Ángel
author
Vicanolo, Tommaso
author
Maccataio, Antonio
author
Benguria, Alberto
author
Li, Jackson LiangYao
author
Adrover, Jose M
author
Aroca-Crevillen, Alejandra
author
Quintana, Juan A.
author
Martin-Salamanca, Sandra
author
Mayo, Francisco
author
Ascher, Stefanie
author
Barbiera, Giulia
author
Soehnlein, Oliver
author
Gunzer, Matthias
author
Ginhoux, Florent
author
Sanchez-Cabo, Fatima
author
Nistal-Villán, Estanislao
author
Schulz, Christian
author
Dopazo, Ana
author
Reinhardt, Christoph
author
Udalova, Irina A
author
Ng, Lai Guan
author
Ostuni, Renato
author
Hidalgo, Andres
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación La Caixa
funder
Fondation Leducq
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Italian Telethon Foundation
funder
Fondazione Cariplo
funder
German Centre for Cardiovascular Research
funder
Fundación ProCNIC
funder
Regional Government of Castile-La Mancha (España)
funder
Boehringer Ingelheim Fonds
2020-12-29T09:02:20Z
2020-12-29T09:02:20Z
2020-11-25
Cell. 2020; 183(5):1282-1297
10.1016/j.cell.2020.10.003
0092-8674
Cell
33098771
http://hdl.handle.net/20.500.12105/11566
Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation. This plastic behavior may underlie variable and even antagonistic functions during inflammation or cancer, yet the full spectrum of neutrophil properties as they enter healthy tissues remains unexplored. Using a new model to track neutrophil fates, we found short but variable lifetimes across multiple tissues. Through analysis of the receptor, transcriptional, and chromatin accessibility landscapes, we identify varying neutrophil states and assign non-canonical functions, including vascular repair and hematopoietic homeostasis. Accordingly, depletion of neutrophils compromised angiogenesis during early age, genotoxic injury, and viral infection, and impaired hematopoietic recovery after irradiation. Neutrophils acquired these properties in target tissues, a process that, in the lungs, occurred in CXCL12-rich areas and relied on CXCR4. Our results reveal that tissues co-opt neutrophils en route for elimination to induce programs that support their physiological demands.
eng
Co-option of Neutrophil Fates by Tissue Environments.
journal article
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URL
https://repisalud.isciii.es/bitstreams/41dc3722-8f1e-48c3-8068-cbc4c72a7d83/download
File
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application/pdf
Co-optionNeutrophilFatesTissue_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/7676c7d4-1047-4888-9df9-6e0fb3380b16/download
File
MD5
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text/plain
Co-optionNeutrophilFatesTissue_2020.pdf.txt