2026-06-14T02:28:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/115662024-09-27T08:20:00Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607

00925njm 22002777a 4500 dc Ballesteros, Ivan author Rubio-Ponce, Andrea author Genua, Marco author Lusito, Eleonora author Kwok, Immanuel author Fernández-Calvo, Gabriel author Khoyratty, Tariq E author van Grinsven, Erinke author Gonzalez-Hernandez, Sara author Nicolás-Ávila, José Ángel author Vicanolo, Tommaso author Maccataio, Antonio author Benguria, Alberto author Li, Jackson LiangYao author Adrover, Jose M author Aroca-Crevillen, Alejandra author Quintana, Juan A. author Martin-Salamanca, Sandra author Mayo, Francisco author Ascher, Stefanie author Barbiera, Giulia author Soehnlein, Oliver author Gunzer, Matthias author Ginhoux, Florent author Sanchez-Cabo, Fatima author Nistal-Villán, Estanislao author Schulz, Christian author Dopazo, Ana author Reinhardt, Christoph author Udalova, Irina A author Ng, Lai Guan author Ostuni, Renato author Hidalgo, Andres author 2020-11-25 Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation. This plastic behavior may underlie variable and even antagonistic functions during inflammation or cancer, yet the full spectrum of neutrophil properties as they enter healthy tissues remains unexplored. Using a new model to track neutrophil fates, we found short but variable lifetimes across multiple tissues. Through analysis of the receptor, transcriptional, and chromatin accessibility landscapes, we identify varying neutrophil states and assign non-canonical functions, including vascular repair and hematopoietic homeostasis. Accordingly, depletion of neutrophils compromised angiogenesis during early age, genotoxic injury, and viral infection, and impaired hematopoietic recovery after irradiation. Neutrophils acquired these properties in target tissues, a process that, in the lungs, occurred in CXCL12-rich areas and relied on CXCR4. Our results reveal that tissues co-opt neutrophils en route for elimination to induce programs that support their physiological demands. Cell. 2020; 183(5):1282-1297 10.1016/j.cell.2020.10.003 0092-8674 Cell 33098771 http://hdl.handle.net/20.500.12105/11566 Co-option of Neutrophil Fates by Tissue Environments.