2026-08-05T11:42:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/115652024-09-27T07:58:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Tomas-Loba, Antonia
author
Manieri, Elisa
author
Gonzalez-Teran, Barbara
author
Mora, Alfonso
author
Leiva-Vega, Luis
author
Santamans, Ayelen M
author
Romero-Becerra, Rafael
author
Rodríguez, Elena
author
Pintor-Chocano, Aránzazu
author
Feixas, Ferran
author
Lopez, Juan Antonio
author
Caballero, Beatriz
author
Trakala, Marianna
author
Blanco, Óscar
author
Torres, Jorge L
author
Hernández-Cosido, Lourdes
author
Montalvo-Romeral, Valle
author
Matesanz, Nuria
author
Roche-Molina, Marta
author
Bernal, Juan Antonio
author
Mischo, Hannah
author
León, Marta
author
Caballero, Ainoa
author
Miranda-Saavedra, Diego
author
Ruiz-Cabello, Jesus
author
Nevzorova, Yulia A
author
Cubero, Francisco Javier
author
Bravo, Jerónimo
author
Vazquez, Jesus
author
Malumbres, Marcos
author
Marcos, Miguel
author
Osuna, Sílvia
author
Sabio, Guadalupe
funder
Fundación La Caixa
funder
Fundación Ramón Areces
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
European Foundation for the Study of Diabetes
funder
Fundación BBVA
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Instituto de Salud Carlos III
funder
Junta de Castilla y León (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Fundación La Marató TV3
2020-12-29T08:34:26Z
2020-12-29T08:34:26Z
2019-04
Nature. 2019; 568(7735):557-60
10.1038/s41586-019-1112-8
Nature
30971822
http://hdl.handle.net/20.500.12105/11565
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex1. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK gamma (p38γ) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. p38γ shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38γ or treatment with the p38γ inhibitor pirfenidone protects against the chemically induced formation of liver tumours. Furthermore, biopsies of human hepatocellular carcinoma show high expression of p38γ, suggesting that p38γ could be a therapeutic target in the treatment of this disease.
eng
p38γ is essential for cell cycle progression and liver tumorigenesis.
journal article
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p38gammaEssentialCellCycle_2019.pdf
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https://repisalud.isciii.es/bitstreams/84c32b1c-0030-4782-94e7-8fe39db78409/download
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text/plain
p38gammaEssentialCellCycle_2019.pdf.txt