2026-06-14T03:44:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/115042024-09-27T09:36:08Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
MacGrogan, Donal
author
Munch, Juliane
author
de la Pompa, Jose Luis
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación BBVA
funder
Fundación La Marató TV3
funder
Fundación ProCNIC
funder
Centro de Investigación Biomedica en Red - CIBER
2020-12-10T11:52:09Z
2020-12-10T11:52:09Z
2018-10
Nat Rev Cardiol. 2018; 15(11):685-704
10.1038/s41569-018-0100-2
1759-5002
Nature reviews. Cardiology
30287945
http://hdl.handle.net/20.500.12105/11504
Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue-tissue interactions. Notch is an intercellular signalling pathway crucial for cell fate decisions during multicellular organismal development and is aptly positioned to coordinate the complex signalling crosstalk required for progressive cell lineage restriction during cardiogenesis. In this Review, we describe the role of Notch signalling and the crosstalk with other signalling pathways during the differentiation and patterning of the different cardiac tissues and in cardiac valve and ventricular chamber development. We examine how perturbation of Notch signalling activity is linked to congenital heart diseases affecting the neonate and adult, and discuss studies that shed light on the role of Notch signalling in heart regeneration and repair after injury.
eng
Notch and interacting signalling pathways in cardiac development, disease, and regeneration.
journal article
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URL
https://repisalud.isciii.es/bitstreams/28c5461b-b31e-421c-b464-931df2ecc409/download
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NotchIinteractingSignallingPathways_2018.pdf
URL
https://repisalud.isciii.es/bitstreams/2dbd0b75-5852-451b-865f-f00effd2d9d1/download
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NotchIinteractingSignallingPathways_2018.pdf.txt