2026-05-22T02:50:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/114952025-06-24T11:30:08Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Machado, Ausenda
author
Kislaya, Irina
author
Larrauri, Amparo
author
Matias Dias, Carlos
author
Nunes, Baltazar
funder
Unión Europea. Comisión Europea. H2020
2020-12-04T07:26:11Z
2020-12-04T07:26:11Z
2019-12-16
BMC Public Health . 2019 Dec 16;19(1):1690.
10.1186/s12889-019-7958-8
1471-2458
BMC public health
31842831
http://hdl.handle.net/20.500.12105/11495
Background: All aged individuals with a chronic condition and those with 65 and more years are at increased risk of severe influenza post-infection complications. There is limited research on cases averted by the yearly vaccination programs in high-risk individuals. The objective was to estimate the impact of trivalent seasonal influenza vaccination on averted hospitalizations and death among the high-risk population in Portugal. Methods: The impact of trivalent seasonal influenza vaccination was estimated using vaccine coverage, vaccine effectiveness and the number of influenza-related hospitalizations and deaths. The number of averted events (NAE), prevented fraction (PF) and number needed to vaccinate (NVN) were estimated for seasons 2014/15 to 2016/17. Results: The vaccination strategy averted on average approximately 1833 hospitalizations and 383 deaths per season. Highest NAE was observed in the ≥65 years population (85% of hospitalizations and 95% deaths) and in the 2016/17 season (1957 hospitalizations and 439 deaths). On average, seasonal vaccination prevented 21% of hospitalizations in the population aged 65 and more, and 18.5% in the population with chronic conditions. The vaccination also prevented 29% and 19.5% of deaths in each group of the high-risk population. It would be needed to vaccinate 3360 high-risk individuals, to prevent one hospitalization and 60,471 high-risk individuals to prevent one death. Conclusion: The yearly influenza vaccination campaigns had a sustained positive benefit for the high-risk population, reducing hospitalizations and deaths. These results can support public health plans toward increased vaccine coverage in high-risk groups.
eng
Impact of national influenza vaccination strategy in severe influenza outcomes among the high-risk Portuguese population
research article
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URL
https://repisalud.isciii.es/bitstreams/a63f7629-be7f-48aa-b32d-0019f9121f5d/download
File
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ImpactOfNationalInfluenza_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/9f7bf976-3596-456c-9669-068fd4226e36/download
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ImpactOfNationalInfluenza_2019.pdf.txt