2026-06-14T03:39:21Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/114782025-06-13T10:47:12Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322com_20.500.12105_2052col_20.500.12105_19605col_20.500.12105_16961col_20.500.12105_19617
Repisalud
author
Gallizioli, Mattia
author
Miró-Mur, Francesc
author
Otxoa-de-Amezaga, Amaia
author
Cugota, Roger
author
Salas-Perdomo, Angélica
author
Justicia, Carles
author
Brait, Vanessa H
author
Ruiz-Jaén, Francisca
author
Arbaizar-Rovirosa, Maria
author
Pedragosa, Jordi
author
Bonfill-Teixidor, Ester
author
Gelderblom, Mathias
author
Magnus, Tim
author
Cano, Eva
author
del Fresno, Carlos
author
Sancho, David
author
Planas, Anna M
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea
funder
Fundación La Marató TV3
funder
Centro Nacional de Investigaciones Cardiovasculares Carlos III (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Government of Catalonia (España)
funder
Asociación Española Contra el Cáncer
2020-12-01T09:02:21Z
2020-12-01T09:02:21Z
2020-10-20
Cell Rep. 2020; 33(3):108291
10.1016/j.celrep.2020.108291
2211-1247
Cell reports
33086061
http://hdl.handle.net/20.500.12105/11478
Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions remain largely unknown. We report that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and astroglia produce Flt3 ligand, supporting development and expansion of CD11c+ cells. CD11c+ cells in the inflamed brain are a complex population derived from proliferating microglia and infiltrating DCs, including a major subset of OX40L+ conventional cDC2, and also cDC1, plasmacytoid, and monocyte-derived DCs. Despite sharing certain morphological features and markers, CD11c+ microglia and DCs display differential expression of pattern recognition receptors and chemokine receptors. DCs excel CD11c- and CD11c+ microglia in the capacity to present antigen through MHCI and MHCII. Of note, cDC1s protect from brain injury after ischemia. We thus reveal aspects of the dynamics and functions of brain DCs in the regulation of inflammation and immunity.
eng
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs
research article
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DendriticCellsMicrogliaHave_2020_suppl.pdf
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DendriticCellsMicrogliaHave_2020.pdf.txt
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