2026-05-22T01:43:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/114732025-05-05T14:47:54Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Kafatos, G
author
Andrews, N
author
McConway, K J
author
Anastassopoulou, C
author
Barbara, C
author
De Ory, Fernando de
author
Johansen, K
author
Mossong, J
author
Prosenc, K
author
Vranckx, R
author
Nardone, A
author
Pebody, Richard
author
Farrington, P
funder
Unión Europea. Comisión Europea
2020-12-01T07:28:19Z
2020-12-01T07:28:19Z
2015-08
Epidemiol Infect. 2015 Aug;143(11):2269-78.
10.1017/S095026881400301X
1469-4409
Epidemiology and infection
25420586
http://hdl.handle.net/20.500.12105/11473
The aim of the European Sero-Epidemiology Network 2 (ESEN2) project was to estimate age-specific seroprevalence for a number of vaccine-preventable diseases in Europe. To achieve this serosurveys were collected by 22 national laboratories. To adjust for a variety of laboratory methods and assays, all quantitative results were transformed to a reference laboratory's units and were then classified as positive or negative to obtain age-specific seroprevalence. The aim of this study was to assess the value of standardization by comparing the crude and standardized seroprevalence estimates. Seroprevalence was estimated for measles, mumps, rubella, diphtheria, varicella zoster and hepatitis A virus (HAV) and compared before and after serological results had been standardized. The results showed that if no such adjustment had taken place, seroprevalence would have differed by an average of 3·2% (95% bootstrap interval 2·9-3·6) although this percentage varied substantially by antigen. These differences were as high as 16% for some serosurveys (HAV) which means that standardization could have a considerable impact on seroprevalence estimates and should be considered when comparing serosurveys performed in different laboratories using different assay methods.
eng
ESEN2
Seroprevalence
Serosurvey
Standardization
Vaccination
Estimating seroprevalence of vaccine-preventable infections: is it worth standardizing the serological outcomes to adjust for different assays and laboratories?
research article
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EstimatingSeroprevalenceVaccinePreventable_2015.pdf
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EstimatingSeroprevalenceOfVaccine_2015.pdf.txt
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EstimatingSeroprevalenceVaccinePreventable_2015.pdf.txt