2026-08-05T15:04:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/114642025-04-03T18:38:04Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16969
Repisalud
author
Guerrero-Torres, M D
author
Menéndez, MB
author
Guerras, CS
author
Tello, E
author
Ballesteros, J
author
Clavo, P
author
Puerta, T
author
Vera, M
author
Ayerdi, O
author
Carrio, J C
author
Mozo, I
author
Del Romero, Jorge
author
Vazquez-Moreno, Julio Alberto
author
Abad, Raquel
funder
Instituto de Salud Carlos III
2020-11-30T09:54:13Z
2020-11-30T09:54:13Z
2019
Epidemiol Infect . 2019 Sep 24;147:e274.
10.1017/S095026881900150X
1469-4409
Epidemiology and infection
31547889
http://hdl.handle.net/20.500.12105/11464
With the aim to elucidate gonococcal antimicrobial resistance (AMR)-risk factors, we undertook a retrospective analysis of the molecular epidemiology and AMR of 104 Neisseria gonorrhoeae isolates from clinical samples (urethra, rectum, pharynx and cervix) of 94 individuals attending a sexually transmitted infection clinic in Madrid (Spain) from July to October 2016, and explored potential links with socio-demographic, behavioural and clinical factors of patients. Antimicrobial susceptibility was determined by E-tests, and isolates were characterised by N. gonorrhoeae multi-antigen sequence typing. Penicillin resistance was recorded for 15.4% of isolates, and most were susceptible to NG-MASTtetracycline, cefixime and azithromycin; a high incidence of ciprofloxacin resistance (~40%) was found. Isolates were grouped into 51 different sequence types (STs) and 10 genogroups (G), with G2400, ST5441, ST2318, ST12547 and G2992 being the most prevalent. A significant association (P = 0.015) was evident between HIV-positive MSM individuals and having a ciprofloxacin-resistant strain. Likewise, a strong association (P = 0.047) was found between patient age of MSM and carriage of isolates expressing decreased susceptibility to azithromycin. A decrease in the incidence of AMR gonococcal strains and a change in the strain populations previously reported from other parts of Spain were observed. Of note, the prevalent multi-drug resistant genogroup G1407 was represented by only three strains in our study, while the pan-susceptible clones such as ST5441, and ST2318, associated with extragenital body sites were the most prevalent.
eng
Antimicrobial resistance
Epidemiology
Neisseria gonorrhoeae
Risk factors
Epidemiology, molecular characterisation and antimicrobial susceptibility of Neisseria gonorrhoeae isolates in Madrid, Spain, in 2016.
research article
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EpidemiologyMolecularCharacterisationAnd_2019.pdf
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EpidemiologyMolecularCharacterisationAnd_2019.pdf.txt