2026-06-14T03:52:22Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/113982024-11-29T20:10:23Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Arem, Hannah
author
Yu, Kai
author
Xiong, Xiaoqin
author
Moy, Kristin
author
Freedman, Neal D
author
Mayne, Susan T
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Albanes, Demetrius
author
Arslan, Alan A
author
Austin, Melissa
author
Bamlet, William R
author
Beane-Freeman, Laura
author
Bracci, Paige
author
Canzian, Federico
author
Cotterchio, Michelle
author
Duell, Eric J
author
Gallinger, Steve
author
Giles, Graham G
author
Goggins, Michael
author
Goodman, Phyllis J
author
Hartge, Patricia
author
Hassan, Manal
author
Helzlsouer, Kathy
author
Henderson, Brian
author
Holly, Elizabeth A
author
Hoover, Robert
author
Jacobs, Eric J
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Kamineni, Aruna
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Klein, Alison
author
Klein, Eric
author
Kolonel, Laurence N
author
Li, Donghui
author
Männistö, Satu
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McCullough, Marjorie L
author
Olson, Sara H
author
Orlow, Irene
author
Peters, Ulrike
author
Petersen, Gloria M
author
Porta, Miquel
author
Severi, Gianluca
author
Shu, Xiao-Ou
author
Visvanathan, Kala
author
White, Emily
author
Yu, Herbert
author
Zeleniuch-Jacquotte, Anne
author
Zheng, Wei
author
Tobias, Geoffrey S
author
Maeder, Dennis
author
Brotzman, Michelle
author
Risch, Harvey
author
Sampson, Joshua N
author
Stolzenberg-Solomon, Rachael Z
author
Malats, Nuria
funder
United States Department of Health and Human Services
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
2020-11-23T11:27:55Z
2020-11-23T11:27:55Z
2015-03-23
PLoS One. 2015 ;10(3):e0117574
10.1371/journal.pone.0117574
PloS one
25799011
http://hdl.handle.net/20.500.12105/11398
Evidence on the association between vitamin D status and pancreatic cancer risk is inconsistent. This inconsistency may be partially attributable to variation in vitamin D regulating genes. We selected 11 vitamin D-related genes (GC, DHCR7, CYP2R1, VDR, CYP27B1, CYP24A1, CYP27A1, RXRA, CRP2, CASR and CUBN) totaling 213 single nucleotide polymorphisms (SNPs), and examined associations with pancreatic adenocarcinoma. Our study included 3,583 pancreatic cancer cases and 7,053 controls from the genome-wide association studies of pancreatic cancer PanScans-I-III. We used the Adaptive Joint Test and the Adaptive Rank Truncated Product statistic for pathway and gene analyses, and unconditional logistic regression for SNP analyses, adjusting for age, sex, study and population stratification. We examined effect modification by circulating vitamin D concentration (≤50, >50 nmol/L) for the most significant SNPs using a subset of cohort cases (n = 713) and controls (n = 878). The vitamin D metabolic pathway was not associated with pancreatic cancer risk (p = 0.830). Of the individual genes, none were associated with pancreatic cancer risk at a significance level of p<0.05. SNPs near the VDR (rs2239186), LRP2 (rs4668123), CYP24A1 (rs2762932), GC (rs2282679), and CUBN (rs1810205) genes were the top SNPs associated with pancreatic cancer (p-values 0.008-0.037), but none were statistically significant after adjusting for multiple comparisons. Associations between these SNPs and pancreatic cancer were not modified by circulating concentrations of vitamin D. These findings do not support an association between vitamin D-related genes and pancreatic cancer risk. Future research should explore other pathways through which vitamin D status might be associated with pancreatic cancer risk.
eng
Vitamin D metabolic pathway genes and pancreatic cancer risk.
journal article
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