2026-06-14T03:54:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/113882024-11-29T13:47:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Martín-Moreno, Ana M
author
Mata, Elena
author
Jiménez, Scherezade
author
Reyes-García, Ana I
author
Rubio, Carmen
author
Tomás, José F
author
Estévez, Mónica
author
Pulford, Karen
author
Piris, Miguel A
author
García, Juan F
author
Roncador, Giovanna
author
Maestre, Maestre L
author
Martinez Torrecuadrada, Jorge Luis
funder
Asociación Española Contra el Cáncer
funder
Unión Europea
funder
Ministerio de Ciencia e Innovación (España)
2020-11-20T11:13:27Z
2020-11-20T11:13:27Z
2015-06-12
PLoS One . 2015 ;10(6):e0125203.
10.1371/journal.pone.0125203
PloS one
26066800
http://hdl.handle.net/20.500.12105/11388
Tumour-associated macrophages (TAMs) have been associated with survival in classic Hodgkin lymphoma (cHL) and other lymphoma types. The maturation and differentiation of tissue macrophages depends upon interactions between colony-stimulating factor 1 receptor (CSF1R) and its ligands. There remains, however, a lack of consistent information on CSF1R expression in TAMs. A new monoclonal antibody, FER216, was generated to investigate CSF1R protein distribution in formalin fixed tissue samples from 24 reactive lymphoid tissues and 187 different lymphoma types. We also analysed the distribution of CSF1R+, CD68+ and CD163+ macrophages by double immunostaining, and studied the relationship between CSF1R expression and survival in an independent series of 249 cHL patients. CSF1R+ TAMs were less frequent in B-cell lymphocytic leukaemia and lymphoblastic B-cell lymphoma than in diffuse large B-cell lymphoma, peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and cHL. HRS cells in cHL and, with the exception of three cases of anaplastic large cell lymphoma, the neoplastic cells in NHLs, lacked detectable CSF1R protein. A CSF1R+ enriched microenvironment in cHL was associated with shorter survival in an independent series of 249 cHL patients. CSF1R pathway activation was evident in the cHL and inactivation of this pathway could be a potential therapeutic target in cHL cases.
eng
TUMOR-ASSOCIATED MACROPHAGES
COLONY-STIMULATING FACTOR
REED-STERNBERG CELLS
FOLLICULAR LYMPHOMA
FACTOR-I
SURVIVAL
PROGRESSION
PROGNOSIS
MICROENVIRONMENT
INHIBITORS
CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma.
journal article
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