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oai:repisalud.isciii.es:20.500.12105/113882024-11-29T13:47:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Martín-Moreno, Ana M author Mata, Elena author Jiménez, Scherezade author Reyes-García, Ana I author Rubio, Carmen author Tomás, José F author Estévez, Mónica author Pulford, Karen author Piris, Miguel A author García, Juan F author Roncador, Giovanna author Maestre, Maestre L author Martinez Torrecuadrada, Jorge Luis author 2015-06-12 Tumour-associated macrophages (TAMs) have been associated with survival in classic Hodgkin lymphoma (cHL) and other lymphoma types. The maturation and differentiation of tissue macrophages depends upon interactions between colony-stimulating factor 1 receptor (CSF1R) and its ligands. There remains, however, a lack of consistent information on CSF1R expression in TAMs. A new monoclonal antibody, FER216, was generated to investigate CSF1R protein distribution in formalin fixed tissue samples from 24 reactive lymphoid tissues and 187 different lymphoma types. We also analysed the distribution of CSF1R+, CD68+ and CD163+ macrophages by double immunostaining, and studied the relationship between CSF1R expression and survival in an independent series of 249 cHL patients. CSF1R+ TAMs were less frequent in B-cell lymphocytic leukaemia and lymphoblastic B-cell lymphoma than in diffuse large B-cell lymphoma, peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and cHL. HRS cells in cHL and, with the exception of three cases of anaplastic large cell lymphoma, the neoplastic cells in NHLs, lacked detectable CSF1R protein. A CSF1R+ enriched microenvironment in cHL was associated with shorter survival in an independent series of 249 cHL patients. CSF1R pathway activation was evident in the cHL and inactivation of this pathway could be a potential therapeutic target in cHL cases. PLoS One . 2015 ;10(6):e0125203. 10.1371/journal.pone.0125203 PloS one 26066800 http://hdl.handle.net/20.500.12105/11388 TUMOR-ASSOCIATED MACROPHAGES COLONY-STIMULATING FACTOR REED-STERNBERG CELLS FOLLICULAR LYMPHOMA FACTOR-I SURVIVAL PROGRESSION PROGNOSIS MICROENVIRONMENT INHIBITORS CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma.