2026-07-16T10:48:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/113532025-06-23T16:36:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16969col_20.500.12105_25179
Repisalud
author
Casado, Concepcion
author
Pernas, Maria
author
Rava, Marta
author
Ayerdi, Oskar
author
Vera, Mar
author
Alenda, Raquel
author
Jimenez Sancho, Maria Pilar
author
Docando, Felix
author
Olivares, Isabel
author
Zaballos, Ángel
author
Vicario, José Luis
author
Rodríguez, Carmen
author
Del Romero, Jorge
author
Lopez-Galindez, Luis Cecilio
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-11-17T12:49:58Z
2020-11-17T12:49:58Z
2020-08-19
AIDS Res Hum Retroviruses. 2020; 36 (11): 896-904
10.1089/AID.2020.0068
1931-8405
AIDS research and human retroviruses
32722915
http://hdl.handle.net/20.500.12105/11353
Data on the prevalence of double infection (DI) in HIV individuals are lacking in Spain. To fill this gap, we analyzed the prevalence of DI in a cohort of men who have sex with men (MSM) and examined factors contributing to DI. We selected 81 MSM attending Centro Sanitario Sandoval, a sexually transmitted diseases clinic in Madrid. We obtained by ultra-deep sequencing the proviral sequences in gag and env genes and performed a phylogenetic analysis for the identification of DI. Clinical, behavioral, host, and viral factors were studied for its association with DI. We detected six individuals with DI and one case of superinfection with a global prevalence of 8.6%. The genetic distance among the subtype B viruses in monoinfected individuals (24.4%) was lower than the distance between the two viruses in subtype B DI individuals (29.5%). Individuals with a high number of sexual contacts (>25 partners/year) had an 8.66 times higher risk of DI (p = .017). In this MSM cohort the prevalence of HIV DI was estimated at 8.6%. DI was strongly associated with the number of sexual partners. Because of the pathogenic consequences of HIV DI, this high prevalence should promote public health programs targeted at high-risk population such as MSM for the control of HIV infection and DI. HIV DI should be considered for a better clinical management of these individuals.
eng
HIV double infection
MSM
Madrid
Prevalence
Risk practices
Sexual partners
Viral genetic variability
High-Risk Sexual Practices Contribute to HIV-1 Double Infection Among Men Who Have Sex with Men in Madrid.
research article
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