2026-05-17T01:16:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/113532025-06-23T16:36:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16969col_20.500.12105_25179

00925njm 22002777a 4500 dc Casado, Concepcion author Pernas, Maria author Rava, Marta author Ayerdi, Oskar author Vera, Mar author Alenda, Raquel author Jimenez Sancho, Maria Pilar author Docando, Felix author Olivares, Isabel author Zaballos, Ángel author Vicario, José Luis author Rodríguez, Carmen author Del Romero, Jorge author Lopez-Galindez, Luis Cecilio author 2020-08-19 Data on the prevalence of double infection (DI) in HIV individuals are lacking in Spain. To fill this gap, we analyzed the prevalence of DI in a cohort of men who have sex with men (MSM) and examined factors contributing to DI. We selected 81 MSM attending Centro Sanitario Sandoval, a sexually transmitted diseases clinic in Madrid. We obtained by ultra-deep sequencing the proviral sequences in gag and env genes and performed a phylogenetic analysis for the identification of DI. Clinical, behavioral, host, and viral factors were studied for its association with DI. We detected six individuals with DI and one case of superinfection with a global prevalence of 8.6%. The genetic distance among the subtype B viruses in monoinfected individuals (24.4%) was lower than the distance between the two viruses in subtype B DI individuals (29.5%). Individuals with a high number of sexual contacts (>25 partners/year) had an 8.66 times higher risk of DI (p = .017). In this MSM cohort the prevalence of HIV DI was estimated at 8.6%. DI was strongly associated with the number of sexual partners. Because of the pathogenic consequences of HIV DI, this high prevalence should promote public health programs targeted at high-risk population such as MSM for the control of HIV infection and DI. HIV DI should be considered for a better clinical management of these individuals. AIDS Res Hum Retroviruses. 2020; 36 (11): 896-904 10.1089/AID.2020.0068 1931-8405 AIDS research and human retroviruses 32722915 http://hdl.handle.net/20.500.12105/11353 HIV double infection MSM Madrid Prevalence Risk practices Sexual partners Viral genetic variability High-Risk Sexual Practices Contribute to HIV-1 Double Infection Among Men Who Have Sex with Men in Madrid.