2026-08-30T13:04:25Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/113512024-11-29T13:35:09Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
De Bonis, Maria Luigia
author
Dominguez, Orlando
author
Pisano, David G
author
Lopez de Silanes, Isabel
author
Graña Castro, Osvaldo
author
Blasco, MA
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Fundación Lilly
funder
Botín Foundation
funder
Fundación AXA
2020-11-17T10:47:45Z
2020-11-17T10:47:45Z
2014-09-03
Nat Commun. 2014;5:4723.
10.1038/ncomms5723
Nature communications
25182072
http://hdl.handle.net/20.500.12105/11351
Telomeric RNAs (TERRAs) are UUAGGG repeat-containing RNAs that are transcribed from the subtelomere towards the telomere. The precise genomic origin of TERRA has remained elusive. Using a whole-genome RNA-sequencing approach, we identify novel mouse transcripts arising mainly from the subtelomere of chromosome 18, and to a lesser extend chromosome 9, that resemble TERRA in several key aspects. Those transcripts contain UUAGGG-repeats and are heterogeneous in size, fluctuate in abundance in a TERRA-like manner during the cell cycle, are bound by TERRA RNA-binding proteins and are regulated in a manner similar to TERRA in response to stress and the induction of pluripotency. These transcripts are also found to associate with nearly all chromosome ends and downregulation of the transcripts that originate from chromosome 18 causes a reduction in TERRA abundance. Interestingly, downregulation of either chromosome 18 transcripts or TERRA results in increased number of telomere dysfunction-induced foci, suggesting a protective role at telomeres.
eng
Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.
journal article
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IdentificationofTERRAlocus_2020.pdf.txt
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