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oai:repisalud.isciii.es:20.500.12105/113512024-11-29T13:35:09Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc De Bonis, Maria Luigia author Dominguez, Orlando author Pisano, David G author Lopez de Silanes, Isabel author Graña Castro, Osvaldo author Blasco, MA author 2014-09-03 Telomeric RNAs (TERRAs) are UUAGGG repeat-containing RNAs that are transcribed from the subtelomere towards the telomere. The precise genomic origin of TERRA has remained elusive. Using a whole-genome RNA-sequencing approach, we identify novel mouse transcripts arising mainly from the subtelomere of chromosome 18, and to a lesser extend chromosome 9, that resemble TERRA in several key aspects. Those transcripts contain UUAGGG-repeats and are heterogeneous in size, fluctuate in abundance in a TERRA-like manner during the cell cycle, are bound by TERRA RNA-binding proteins and are regulated in a manner similar to TERRA in response to stress and the induction of pluripotency. These transcripts are also found to associate with nearly all chromosome ends and downregulation of the transcripts that originate from chromosome 18 causes a reduction in TERRA abundance. Interestingly, downregulation of either chromosome 18 transcripts or TERRA results in increased number of telomere dysfunction-induced foci, suggesting a protective role at telomeres. Nat Commun. 2014;5:4723. http://hdl.handle.net/20.500.12105/11351 25182072 10.1038/ncomms5723 Nature communications Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.