2026-04-29T04:09:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/113482025-06-13T08:36:36Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
García-Jiménez, Custodia
author
Gutiérrez-Salmerón, María
author
Chocarro-Calvo, Ana
author
García-Martínez, José Manuel
author
Castaño, Angel
author
De la Vieja, Antonio
funder
Instituto de Salud Carlos III
funder
King Juan Carlos University (España)
funder
Banco Santander
funder
European Molecular Biology Organization
funder
Marie Curie
2020-11-16T16:55:28Z
2020-11-16T16:55:28Z
2016-03-29
Br J Cancer . 2016 Mar 29;114(7):716-22.
http://hdl.handle.net/20.500.12105/11348
26908326
10.1038/bjc.2016.37
1532-1827
British journal of cancer
Increasing evidence suggests a complex relationship between obesity, diabetes and cancer. Here we review the evidence for the association between obesity and diabetes and a wide range of cancer types. In many cases the evidence for a positive association is strong, but for other cancer types a more complex picture emerges with some site-specific cancers associated with obesity but not to diabetes, and some associated with type I but not type II diabetes. The evidence therefore suggests the existence of cumulative common and differential mechanisms influencing the relationship between these diseases. Importantly, we highlight the influence of antidiabetics on cancer and antineoplastic agents on diabetes and in particular that antineoplastic targeting of insulin/IGF-1 signalling induces hyperglycaemia that often evolves to overt diabetes. Overall, a coincidence of diabetes and cancer worsens outcome and increases mortality. Future epidemiology should consider dose and time of exposure to both disease and treatment, and should classify cancers by their molecular signatures. Well-controlled studies on the development of diabetes upon cancer treatment are necessary and should identify the underlying mechanisms responsible for these reciprocal interactions. Given the global epidemic of diabetes, preventing both cancer occurrence in diabetics and the onset of diabetes in cancer patients will translate into a substantial socioeconomic benefit.
eng
From obesity to diabetes and cancer: epidemiological links and role of therapies
research article
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FromObesityToDiabetes_2016.pdf
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FromObesityToDiabetes_2016_SupplementaryInformation.pdf
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FromObesityToDiabetes_2016.pdf.txt
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FromObesityToDiabetes_2016_SupplementaryInformation.pdf.txt