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oai:repisalud.isciii.es:20.500.12105/112862025-06-19T13:24:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19613
Repisalud author Tschiderer, Lena author Seekircher, Lisa author Klingenschmid, Gerhard author Izzo, Raffaele author Baldassarre, Damiano author Iglseder, Bernhard author Calabresi, Laura author Liu, Jing author Price, Jackie F author Bae, Jang-Ho author Brouwers, Frank P author de Groot, Eric author Schmidt, Caroline author Bergström, Göran author Aşçi, Gülay author Gresele, Paolo author Okazaki, Shuhei author Kapellas, Kostas author Landecho, Manuel F author Sattar, Naveed author Agewall, Stefan author Zou, Zhi-Yong author Byrne, Christopher D author Nanayakkara, Prabath W B author Papagianni, Aikaterini author Witham, Miles D author Bernal, Enrique author Ekart, Robert author van Agtmael, Michiel A author Neves, Mario F author Sato, Eiichi author Ezhov, Marat author Walters, Matthew author Olsen, Michael H author Stolić, Radojica author Zozulińska-Ziółkiewicz, Dorota A author Hanefeld, Markolf author Staub, Daniel author Nagai, Michiaki author Nieuwkerk, Pythia T author Huisman, Menno V author Kato, Akihiko author Honda, Hirokazu author Parraga, Grace author Magliano, Dianna author Gabriel-Sanchez, Rafael author Rundek, Tatjana author Espeland, Mark A author Kiechl, Stefan author Willeit, Johann author Lind, Lars author Empana, Jean Philippe author Lonn, Eva author Tuomainen, Tomi-Pekka author Catapano, Alberico author Chien, Kuo-Liong author Sander, Dirk author Kavousi, Maryam author Beulens, Joline W J author Bots, Michiel L author Sweeting, Michael J author Lorenz, Matthias W author Willeit, Peter funder FWF Austrian Science Fund 2020-11-04T12:31:03Z 2020-11-04T12:31:03Z 2020 Gerontology. 2020;66(5):447-459. 10.1159/000508498 1423-0003 0304-324X Gerontology 32610336 http://hdl.handle.net/20.500.12105/11286 Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosis -(Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. In summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. The consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences. eng The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale research article 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 URL https://repisalud.isciii.es/bitstreams/d403f7c2-e9d4-4ca4-a7b3-e8f2655b39ec/download File MD5 ab505402ef530c91d31e1cb6598b93a3 1554174 application/pdf TheProspectiveStudiesOf_2020.pdf URL https://repisalud.isciii.es/bitstreams/2b7f28c6-a271-4af3-820b-4761b652fa46/download File MD5 8ebb1f4817234961969fb4f605ded0fd 1321298 application/pdf TheProspectiveStudiesOf_2020SupplementaryMaterial.pdf URL https://repisalud.isciii.es/bitstreams/4ad97bdc-cc7d-449a-ab48-dca5f9aeb88e/download File MD5 3dc11635be594762cf54e24ee1937754 55198 text/plain TheProspectiveStudiesOf_2020.pdf.txt URL https://repisalud.isciii.es/bitstreams/8d01ea28-d1ff-4641-82d6-60e7e8412614/download File MD5 03f1e4bebef049d28e1c3e67176de55a 37607 text/plain TheProspectiveStudiesOf_2020SupplementaryMaterial.pdf.txt