2026-04-29T04:09:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/112622024-09-27T09:46:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Bardaji, Alfredo
author
Leal, Manuel
author
Arrarte, Vicente
author
Garcia-Moll, Xavier
author
Pérez de Isla, Leopoldo
author
Bueno, Hector
funder
Fundación AstraZeneca
2020-10-29T14:38:03Z
2020-10-29T14:38:03Z
2017
Cardiovasc Ther. 2017; 35(2):e12237
http://hdl.handle.net/20.500.12105/11262
27885830
10.1111/1755-5922.12237
Cardiovascular therapeutics
Real-world, country-specific studies of dual antiplatelet therapy (DAPT) duration among survivors of acute coronary syndrome (ACS) are important for improving long-term prognosis.
To investigate DAPT duration after hospital discharge for ACS in Spain.
Data from patients enrolled in the Spanish cohort of the EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) study (NCT01171404) were analyzed for changes to antithrombotic medication up to 2 years postdischarge according to index event diagnosis and patient characteristics. Deaths, coronary events, and bleeding events were analyzed over the same period. Overall, a high proportion of patients remained on DAPT at 2 years (53.1%). Among patients who experienced any on-treatment bleeding event, almost two-thirds remained on DAPT at the end of follow-up. Patients >65 years, diabetic, or those that were medically managed were more likely to continue with DAPT until 2 years following discharge. At 2 years, the incidence of bleeding events requiring hospitalization was low compared with the incidence of coronary events (1.4% vs 6.6%). There was a numerical reduction in coronary events, but no increase in bleeding events, with DAPT continuation compared with single antiplatelet therapy.
More than half of patients in this unselected cohort study remained on DAPT at 2 years following discharge for ACS. Continuation with DAPT was greater among patients with additional cardiovascular risk factors, which suggests that treating physicians in Spain prioritizes ischemic risk reduction over bleeding risk in patients with ACS, according to patient's risk profile.
eng
Extended dual antiplatelet therapy after acute coronary syndrome in Spain: Results from the EPICOR study.
journal article
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URL
https://repisalud.isciii.es/bitstreams/8cc2caa2-1e17-482f-83e8-2ef3ce6c8c1c/download
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ExtendedDualAntiplateletTherapy_2017.pdf
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text/plain
ExtendedDualAntiplateletTherapy_2017.pdf.txt