2026-06-14T14:48:05Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/112572024-09-27T08:01:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Fanjul, Victor
author
Jorge, Inmaculada
author
Camafeita, Emilio
author
Macias, Alvaro
author
Gonzalez-Gomez, Cristina
author
Barettino, Ana
author
Dorado, Beatriz
author
Andres-Manzano, Maria J.
author
Rivera-Torres, Jose
author
Vazquez, Jesus
author
López-Otín, Carlos
author
Andres, Vicente
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Fundación La Marató TV3
funder
Fundación La Caixa
funder
Progeria Research Foundation
funder
Fundación ProCNIC
2020-10-29T07:37:26Z
2020-10-29T07:37:26Z
2020-07-30
Aging Cell. 2020; 19(9):e13203
10.1111/acel.13203
1474-9718
Aging cell
32729659
http://hdl.handle.net/20.500.12105/11257
Aging is the main risk factor for cardiovascular and metabolic diseases, which have become a global concern as the world population ages. These diseases and the aging process are exacerbated in Hutchinson-Gilford progeria syndrome (HGPS or progeria). Here, we evaluated the cardiometabolic disease in animal models of premature and normal aging with the aim of identifying alterations that are shared or specific to each condition. Despite differences in body composition and metabolic markers, prematurely and normally aging mice developed heart failure and similar cardiac electrical abnormalities. High-throughput proteomics of the hearts of progeric and normally aged mice revealed altered protein oxidation and glycation, as well as dysregulated pathways regulating energy metabolism, proteostasis, gene expression, and cardiac muscle contraction. These results were corroborated in the hearts of progeric pigs, underscoring the translational potential of our findings, which could help in the design of strategies to prevent or slow age-related cardiometabolic disease.
eng
Identification of common cardiometabolic alterations and deregulated pathways in mouse and pig models of aging.
journal article
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URL
https://repisalud.isciii.es/bitstreams/4bdb7fac-0935-4f57-8788-ff48448e0143/download
File
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application/pdf
IdentificationCommonCardiometabolicAlterations_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/ff36ce06-750e-4a70-84dc-7c5427c5f43c/download
File
MD5
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text/plain
IdentificationCommonCardiometabolicAlterations_2020.pdf.txt