2026-06-30T01:54:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/112562024-09-27T08:09:21Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Grivas, Dimitrios
author
González-Rajal, Álvaro
author
Guerrero Rodríguez, Carlos
author
Garcia, Ricardo
author
de la Pompa, Jose Luis
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Fundación BBVA
funder
Fundación La Marató TV3
funder
Unión Europea. Comisión Europea
funder
Comunidad de Madrid (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2020-10-28T14:19:30Z
2020-10-28T14:19:30Z
2020-07
Sci Rep. 2020; 10(1):12816
10.1038/s41598-020-68802-9
2045-2322
Scientific reports
32733088
http://hdl.handle.net/20.500.12105/11256
Caveolin-1 is the main structural protein of caveolae, small membrane invaginations involved in signal transduction and mechanoprotection. Here, we generated cav1-KO zebrafish lacking Cav1 and caveolae, and investigated the impact of this loss on adult heart function and response to cryoinjury. We found that cardiac function was impaired in adult cav1-KO fish, which showed a significantly decreased ejection fraction and heart rate. Using atomic force microscopy, we detected an increase in the stiffness of epicardial cells and cells of the cortical zone lacking Cav1/caveolae. This loss of cardiac elasticity might explain the decreased cardiac contraction and function. Surprisingly, cav1-KO mutants were able to regenerate their heart after a cryoinjury but showed a transient decrease in cardiomyocyte proliferation.
eng
Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart.
journal article
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LossCaveolin-1CaveolaeLeads_2020.pdf.txt
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