2026-05-17T01:18:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/112492024-11-28T16:27:32Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16938
Repisalud
author
Saez, Angela
author
Herrero-Fernandez, Beatriz
author
Gomez-Bris, Raquel
author
Somovilla-Crespo, Beatriz
author
Rius, Cristina
author
Gonzalez-Granado, Jose Maria
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Autonomous University of Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
2020-10-28T13:43:49Z
2020-10-28T13:43:49Z
2020-08-25
Int J Mol Sci. 2020; 21(17):e6109
10.3390/ijms21176109
1422-0067
International journal of molecular sciences
32854281
http://hdl.handle.net/20.500.12105/11249
Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense fibrous protein meshwork located in the nuclear interior. Lamin A/C proteins regulate nuclear mechanics and structure and control cellular signaling, gene transcription, epigenetic regulation, cell cycle progression, cell differentiation, and cell migration. The immune system is composed of the innate and adaptive branches. Innate immunity is mediated by myeloid cells such as neutrophils, macrophages, and dendritic cells. These cells produce a rapid and nonspecific response through phagocytosis, cytokine production, and complement activation, as well as activating adaptive immunity. Specific adaptive immunity is activated by antigen presentation by antigen presenting cells (APCs) and the cytokine microenvironment, and is mainly mediated by the cellular functions of T cells and the production of antibodies by B cells. Unlike most cell types, immune cells regulate their lamin A/C protein expression relatively rapidly to exert their functions, with expression increasing in macrophages, reducing in neutrophils, and increasing transiently in T cells. In this review, we discuss and summarize studies that have addressed the role played by lamin A/C in the functions of innate and adaptive immune cells in the context of human inflammatory and autoimmune diseases, pathogen infections, and cancer.
eng
Lamin A/C and the Immune System: One Intermediate Filament, Many Faces.
journal article
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LaminACImmuneSystem_2020.pdf
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https://repisalud.isciii.es/bitstreams/fd27ddc7-8ada-47d1-91e9-b6b1d3c9bbbe/download
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LaminACImmuneSystem_2020.pdf.txt