2026-06-14T00:32:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/112402024-09-27T08:57:57Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Bosch, Marta author Sanchez-Alvarez, Miguel author Fajardo, Alba author Kapetanovic, Ronan author Steiner, Bernhard author Dutra, Filipe author Moreira, Luciana author Lopez, Juan Antonio author Campo author Marí, Montserrat author Morales-Paytuví, Frederic author Tort, Olivia author Gubern, Albert author Templin, Rachel M author Curson, James E B author Martel, Nick author Català, Cristina author Lozano, Francisco author Tebar, Francesc author Enrich, Carlos author Vazquez, Jesus author del Pozo, Miguel Angel author Sweet, Matthew J author Bozza, Patricia T author Gross, Steven P author Parton, Robert G author Pol, Albert author 2020-10 Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection. Science. 2020; 370(6514):eaay8085 10.1126/science.aay8085 0036-8075 Science (New York, N.Y.) 33060333 http://hdl.handle.net/20.500.12105/11240 Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.