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oai:repisalud.isciii.es:20.500.12105/112072024-09-27T08:04:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Casanova, José David author González Carrillo, Josefa author Martín Jiménez, Jesús author Cuenca Muñoz, Javier author Muñoz Esparza, Carmen author Siguero-Alvarez, Marcos author Escribá, Rubén author Burillo Milla, Esther author de la Pompa, Jose Luis author Raya, Ángel author Gimeno, Juan Ramón author Sabater Molina, María author Bernabé García, Gregorio author 2020-09-30 Hypertrophic cardiomyopathy (HCM) is often accompanied by increased trabeculated myocardium (TM)-which clinical relevance is unknown. We aim to measure the left ventricular (LV) mass and proportion of trabeculation in an HCM population and to analyze its clinical implication. We evaluated 211 patients with HCM (mean age 47.8 ± 16.3 years, 73.0% males) with cardiac magnetic resonance (CMR) studies. LV trabecular and compacted mass were measured using dedicated software for automatic delineation of borders. Mean compacted myocardium (CM) was 160.0 ± 62.0 g and trabecular myocardium (TM) 55.5 ± 18.7 g. The percentage of trabeculated myocardium (TM%) was 26.7% ± 6.4%. Females had significantly increased TM% compared to males (29.7 ± 7.2 vs. 25.6 ± 5.8, p < 0.0001). Patients with LVEF < 50% had significantly higher values of TM% (30.2% ± 6.0% vs. 26.6% ± 6.4%, p = 0.02). Multivariable analysis showed that female gender and neutral pattern of hypertrophy were directly associated with TM%, while dynamic obstruction, maximal wall thickness and LVEF% were inversely associated with TM%. There was no association between TM% with arterial hypertension, physical activity, or symptoms. Atrial fibrillation and severity of hypertrophy were the only variables associated with cardiovascular death. Multivariable analysis failed to demonstrate any correlation between TM% and arrhythmias. Approximately 25% of myocardium appears non-compacted and can automatically be measured in HCM series. Proportion of non-compacted myocardium is increased in female, non-obstructives, and in those with lower contractility. The amount of trabeculation might help to identify HCM patients prone to systolic heart failure. J Clin Med. 2020; 9(10):3171 10.3390/jcm9103171 2077-0383 Journal of clinical medicine 33007916 http://hdl.handle.net/20.500.12105/11207 Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences.