2026-04-29T11:08:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/111832024-09-27T08:03:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
del Fresno, Carlos
author
Sancho, David
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fondation ACTERIA (Acting on European Research in Immunology and Allergology)
funder
Atresmedia
funder
Fundación La Marató TV3
funder
Fundación ProCNIC
2020-10-19T12:50:50Z
2020-10-19T12:50:50Z
2020-10-06
Curr Opin Immunol. 2020; 68:34-40
10.1016/j.coi.2020.08.006
1879-0372
Current opinion in immunology
33035713
http://hdl.handle.net/20.500.12105/11183
Myeloid cells are components of the innate immune system that represent the first line of defense. Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the extracellular environment. Myeloid cells detect ligands exposed or released by dead cells through specific receptors that signal for a diversity of responses. Inflammatory responses triggered by myeloid cells after sensing tissue injury can contribute to resolution of the damage. The signaling response following dead-cell sensing by myeloid cells can contribute either to an inflammatory or a regulatory response. We review herein some representative examples of how myeloid cells react to the recognition of cell death during specific tissue damage contexts. A deep understanding of the cellular and molecular mechanisms underlying these processes would allow to improve therapeutical interventions in pathologies associated with tissue damage.
eng
Myeloid cells in sensing of tissue damage.
journal article
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URL
https://repisalud.isciii.es/bitstreams/7e185da9-0f36-4b82-a4dc-87acdc0dd708/download
File
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application/pdf
MyeloidCellsSensingTtissue_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/18b878c1-c5b9-4537-909a-a0f23052813d/download
File
MD5
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text/plain
MyeloidCellsSensingTtissue_2020.pdf.txt