2026-05-22T00:30:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/111182024-09-27T08:18:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Peralta, Marina
author
Ortiz Lopez, Laia
author
Jerabkova, Katerina
author
Lucchesi, Tommaso
author
Vitre, Benjamin
author
Han, Dong
author
Guillemot, Laurent
author
Dingare, Chaitanya
author
Sumara, Izabela
author
Mercader, Nadia
author
Lecaudey, Virginie
author
Delaval, Benedicte
author
Meilhac, Sigolène M
author
Vermot, Julien
funder
Unión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Agence Nationale de la Recherche (Francia)
funder
Institut Pasteur
funder
Institut Imagine
2020-10-08T09:55:11Z
2020-10-08T09:55:11Z
2020-07-21
Cell Rep. 2020; 32(3):107932
10.1016/j.celrep.2020.107932
2211-1247
Cell reports
32698004
http://hdl.handle.net/20.500.12105/11118
Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, the molecular links between cilia, IFT proteins, and cardiogenesis are yet to be established. Using a combination of biochemistry, genetics, and live-imaging methods, we show that IFT complex B proteins (Ift88, Ift54, and Ift20) modulate the Hippo pathway effector YAP1 in zebrafish and mouse. We demonstrate that this interaction is key to restrict the formation of the proepicardium and the myocardium. In cellulo experiments suggest that IFT88 and IFT20 interact with YAP1 in the cytoplasm and functionally modulate its activity, identifying a molecular link between cilia-related proteins and the Hippo pathway. Taken together, our results highlight a noncanonical role for IFT complex B proteins during cardiogenesis and shed light on a mechanism of action for ciliary proteins in YAP1 regulation.
eng
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
journal article
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IntraflagellarTransportComplexB_2020.pdf.txt
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