2026-05-22T00:40:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/111182024-09-27T08:18:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Peralta, Marina author Ortiz Lopez, Laia author Jerabkova, Katerina author Lucchesi, Tommaso author Vitre, Benjamin author Han, Dong author Guillemot, Laurent author Dingare, Chaitanya author Sumara, Izabela author Mercader, Nadia author Lecaudey, Virginie author Delaval, Benedicte author Meilhac, Sigolène M author Vermot, Julien author 2020-07-21 Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, the molecular links between cilia, IFT proteins, and cardiogenesis are yet to be established. Using a combination of biochemistry, genetics, and live-imaging methods, we show that IFT complex B proteins (Ift88, Ift54, and Ift20) modulate the Hippo pathway effector YAP1 in zebrafish and mouse. We demonstrate that this interaction is key to restrict the formation of the proepicardium and the myocardium. In cellulo experiments suggest that IFT88 and IFT20 interact with YAP1 in the cytoplasm and functionally modulate its activity, identifying a molecular link between cilia-related proteins and the Hippo pathway. Taken together, our results highlight a noncanonical role for IFT complex B proteins during cardiogenesis and shed light on a mechanism of action for ciliary proteins in YAP1 regulation. Cell Rep. 2020; 32(3):107932 10.1016/j.celrep.2020.107932 2211-1247 Cell reports 32698004 http://hdl.handle.net/20.500.12105/11118 Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.