2026-05-22T23:34:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/110922024-11-30T00:13:30Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Kordowitzki, Paweł
author
López de Silanes, Isabel
author
Guío-Carrión, Ana
author
Blasco, MA
funder
KNOW consortium (Poland MSHE)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Worldwide Cancer Research
funder
Botín Foundation
2020-10-06T07:41:49Z
2020-10-06T07:41:49Z
2020-08-29
Aging (Albany NY). 2020 ;12(16):15906-15917.
10.18632/aging.103922
1945-4589
Aging
32860669
http://hdl.handle.net/20.500.12105/11092
Telomeres are transcribed into long non-coding RNAs known as Telomeric Repeat-Containing RNA (TERRA). They have been shown to be essential regulators of telomeres and to act as epigenomic modulators at extra-telomeric sites. However the role of TERRA during early embryonic development has never been investigated. Here, we show that TERRA is expressed in murine and bovine early development following a wave pattern. It starts at 4-cell stage, reaching a maximum at the 16-cell followed by a decline at the morula and blastocyst stages. Moreover, TERRA expression is not affected by increasing oocyte donor age whereas telomere length does. This indicates that TERRA expression is independent of the telomere length in early development. Our findings anticipate an essential role of TERRA in early stages of development and this might be useful in the future for a better understanding of age related female infertility.
eng
GERM-CELLS
DELAYED CHILDBEARING
TERRA
TRANSCRIPTION
HOMEOSTASIS
ACTIVATION
CLEARANCE
LENGTH
RATES
EZH2
Dynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal age
journal article
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URL
https://repisalud.isciii.es/bitstreams/9e2515cc-8cd7-46b3-bbeb-7dd5fa14a0b9/download
File
MD5
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application/pdf
Dynamicsoftelomericrepeat-containingRNA_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/f5268032-726f-4ff9-9078-b3c427e293fa/download
File
MD5
9483ba398240524bd2242e15d801f765
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text/plain
Dynamicsoftelomericrepeat-containingRNA_2020.pdf.txt