2026-05-22T23:34:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/110922024-11-30T00:13:30Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Kordowitzki, Paweł author López de Silanes, Isabel author Guío-Carrión, Ana author Blasco, MA author 2020-08-29 Telomeres are transcribed into long non-coding RNAs known as Telomeric Repeat-Containing RNA (TERRA). They have been shown to be essential regulators of telomeres and to act as epigenomic modulators at extra-telomeric sites. However the role of TERRA during early embryonic development has never been investigated. Here, we show that TERRA is expressed in murine and bovine early development following a wave pattern. It starts at 4-cell stage, reaching a maximum at the 16-cell followed by a decline at the morula and blastocyst stages. Moreover, TERRA expression is not affected by increasing oocyte donor age whereas telomere length does. This indicates that TERRA expression is independent of the telomere length in early development. Our findings anticipate an essential role of TERRA in early stages of development and this might be useful in the future for a better understanding of age related female infertility. Aging (Albany NY). 2020 ;12(16):15906-15917. 10.18632/aging.103922 1945-4589 Aging 32860669 http://hdl.handle.net/20.500.12105/11092 GERM-CELLS DELAYED CHILDBEARING TERRA TRANSCRIPTION HOMEOSTASIS ACTIVATION CLEARANCE LENGTH RATES EZH2 Dynamics of telomeric repeat-containing RNA expression in early embryonic cleavage stages with regards to maternal age