2026-05-20T23:33:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/110872025-05-08T17:13:19Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16978
Repisalud
author
Carrero, Ana
author
Berenguer, Juan
author
Hontañón, Víctor
author
Guardiola, Josep M
author
Navarro, Jordi
author
Von Wichmann, Miguel A
author
Téllez, María Jesús
author
Quereda, Carmen
author
Santos, Ignacio
author
Sanz, José
author
Galindo, María J
author
Hernández-Quero, José
author
Jimenez-Sousa, Maria Angeles
author
Pérez-Latorre, Leire
author
Bellón, José María
author
Resino, Salvador
author
Esteban, Herminia
author
Martínez, Esteban
author
González-García, Juan
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2020-09-30T09:44:16Z
2020-09-30T09:44:16Z
2020-09-15
Clin Infect Dis. 2021 Oct 5;73(7):e2026-e2033.
10.1093/cid/ciaa1396
1537-6591
Clinical infectious diseases
32930720
http://hdl.handle.net/20.500.12105/11087
Background: Little is known about the effects of eradication of hepatitis C virus (HCV) on bone mineral density (BMD) and biomarkers of bone remodeling in human immunodeficiency virus (HIV)/HCV-coinfected patients. Methods: We prospectively assessed standardized BMD (sBMD) at the lumbar spine and femoral neck, World Health Organization BMD categories at both sites, and plasma concentrations of soluble receptor activator of NF-κβ ligand (sRANKL), and osteoprotegerin (OPG) at baseline (the date of initiation of anti-HCV therapy) and at 96 weeks. Results: A total of 238 patients were included. The median age was 49.5 years, 76.5% were males, 48.3% had cirrhosis, 98.3% were on antiretroviral therapy, median CD4+ cell count was 527 cells/μL, and 86.6% had HIV-1 RNA <50 copies/mL. The prevalence of osteoporosis at baseline at the lumbar spine (LS) and femoral neck (FN) was 17.6% and 7.2%, respectively. Anti-HCV therapy comprised pegylated interferon (peg-IFN) and ribavirin (RBV) plus 1 direct-acting antiviral in 53.4%, peg-IFN/RBV in 34.5%, and sofosbuvir/RBV in 12.2%. A total of 145 (60.9%) patients achieved sustained virologic response (SVR). No significant effect of SVR was observed on sBMD for the interaction between time and SVR either in the LS (P = .801) or the FN (P = .911). Likewise, no significant effect of SVR was observed in plasma levels of sRANKL (P = .205), OPG (P = .249), or sRANKL/OPG ratio (P = .123) for the interaction between time and SVR. No significant correlation was found between fibrosis by transient elastography, and LS and FN sBMD, at baseline and week 96. Conclusions: SVR was not associated with significant changes in BMD nor biomarkers of bone remodeling in HIV/HCV-coinfected persons.
eng
Effects of Hepatitis C Virus (HCV) Eradication on Bone Mineral Density in Human Immunodeficiency Virus/HCV-Coinfected Patients
research article
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File
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application/pdf
EffectsOfHCVEradication_2020.pdf
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https://repisalud.isciii.es/bitstreams/5226f5dc-fba2-434a-80d3-4afbdf07e0e7/download
File
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text/plain
EffectsOfHCVEradication_2020.pdf.txt