2026-07-21T14:27:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/110652024-09-27T08:14:34Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Bär, Christian author Chatterjee, Shambhabi author Falcão Pires, Inês author Rodrigues, Patrícia author Sluijter, Joost P G author Boon, Reinier A author Nevado, Rosa M author Andres, Vicente author Sansonetti, Marida author de Windt, Leon author Ciccarelli, Michele author Hamdani, Nazha author Heymans, Stephane author Figuinha Videira, Raquel author Tocchetti, Carlo G author Giacca, Mauro author Zacchigna, Serena author Engelhardt, Stefan author Dimmeler, Stefanie author Madonna, Rosalinda author Thum, Thomas author 2020-09-01 Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system. Cardiovasc Res. 2020; 116(11):1805-1819 10.1093/cvr/cvaa195 1755-3245 Cardiovascular research 32638021 http://hdl.handle.net/20.500.12105/11065 Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart.